Promising new treatment for dry eye revealed by new research

University of Manchester, Seoul National University College of Medicine and Link Biologics Limited today announced that Promising preclinical data on the treatment of dry eye using a novel protein biologic drug, Link_TSG6, has been published in the peer-reviewed journal, Ocular surface.

Dry eye disease (DED) is the most common ocular surface disorder, affecting around 350 million people worldwide and causing persistent eye irritation, blurred vision, pain and reduced quality of life. DED is characterized by a loss of ocular tear film homeostasis and a vicious cycle of damage and inflammation of the corneal epithelium.

The recently published study evaluated Link_TSG6 in two validated mouse models of DED: an autoimmune model where NOD.B10.H2 mice spontaneously develop dry eye and the desiccation stress model that mimics DED caused by environmental factors. . Study results showed that Link_TSG6 administered topically (e.g., twice daily for 7 days) dose-dependently reduced corneal epithelial defects and suppressed inflammatory markers while increasing tear production and conjunctival goblet cell density. At the highest dose of Link_TSG6, no corneal lesions remained in approximately 50% of treated eyes. Additionally, Link_TSG6 was significantly more effective than Restasisa, the market leading treatment, to reduce corneal epithelial erosions and reduce inflammation.

“There is a desperate need for treatments that rapidly and significantly improve the signs and symptoms of dry eye disease,” said Dr. Joo Youn Oh of Seoul National University College of Medicine, corresponding author. item. “The present findings confirm the viability of Link_TSG6 as a promising drug candidate that both suppresses inflammation and promotes corneal repair – critical steps to overcoming the pathophysiology of dry eye disease.”

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