Eye problems – Web Xpress http://web-xpress.com/ Tue, 30 Nov 2021 13:54:49 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://web-xpress.com/wp-content/uploads/2021/10/icon-9-150x150.png Eye problems – Web Xpress http://web-xpress.com/ 32 32 Shocking images show what diabetes REALLY looks like for millions of people https://web-xpress.com/shocking-images-show-what-diabetes-really-looks-like-for-millions-of-people/ Tue, 30 Nov 2021 13:04:00 +0000 https://web-xpress.com/shocking-images-show-what-diabetes-really-looks-like-for-millions-of-people/ THESE shocking images give an idea of ​​what millions of people with diabetes have struggled against. Wavy vision, blurry vision, floaters, loss of color, and complete loss of vision are all symptoms of diabetes. 5 The vision of diabetics can become wavy, as shown using a very fragile looking Tower BridgeCredit: Lenstore The disease occurs […]]]>

THESE shocking images give an idea of ​​what millions of people with diabetes have struggled against.

Wavy vision, blurry vision, floaters, loss of color, and complete loss of vision are all symptoms of diabetes.

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The vision of diabetics can become wavy, as shown using a very fragile looking Tower BridgeCredit: Lenstore

The disease occurs when a person cannot produce enough insulin to control blood sugar levels or their insulin does not work effectively.

Most people know that diabetes, both types 1 and 2, is when a person has to constantly manage their blood sugar.

But did you know that one of the main complications of the disease is vision problems, among many others?

This happens because too much sugar in the blood over time can lead to the blockage of the tiny blood vessels that nourish the retina.

The retina is a layer of tissue at the back of the eye that senses light and sends images to the brain. It is vital to be able to see correctly what is in front of you.

Damage to the retina cuts off the blood supply, and as a result, the eye tries to develop new blood vessels, the Mayo Clinic explains.

But these new blood vessels don’t grow properly and can leak easily. This causes a whole host of problems for the vision.

More than 4.9 million people in the UK have diabetes, and an estimated 850,000 more are living with this undiagnosed diabetes.

According to Lenstore, some 1,700 people with diabetes have their eyesight severely affected by their disease each year in the UK.

Roshni Patel, Expert Optometrist and Eye Specialist at Lenstore, said: “If you are facing a change in vision, whether it is blurring, distortions or the ability to perceive things at different distances. , it is always important to speak to your optometrist as soon as possible. .

“Blurring and distortion can be a sign of something serious, and the sooner you catch a risk, the better the chances that it can be treated. “

The contact lens supplier has produced a series of photos illustrating how diabetes can cause vision distortion using landmarks in the UK.

Wavy vision

High blood sugar can cause the lens of your eye to swell, which can cause your vision to be distorted.

The effects of this can be both short term and long term.

Blurred vision

Short-term vision loss is often the result of fluids entering and leaving the eye due to high blood sugar, which can then cause the lens to swell.

Since the lens is the part that focuses on the light, this is where the blurry view emerges.

The long term effects of blurred vision often come from uncontrolled diabetes and result from high blood sugar damaging small blood vessels over a period of time.

The retina is affected, causing you to experience blurry vision.

Stone Henge isn't quite the same when blurry

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Stone Henge isn’t quite the same when he’s out of focusCredit: Lenstore

Floats

Floaters appear as white or translucent visual blockers that come and go and move around in your vision.

These floaters can often be a symptom of a more serious diabetes-related eye condition, such as diabetic retinopathy.

Diabetic retinopathy occurs when the blood vessels in your retina are damaged.

Floaters can also be a sign of diabetic macular edema, which sees fluid build-up in the center of the retina or macular.

The maclar is the area of ​​the eye responsible for your sharp vision and most of your color vision.

Floaters can appear in vision if diabetes has damaged your eyesight, ruining magnificent sights such as Kilchurn Castle, Scotland

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Floaters can appear in vision if diabetes has damaged your eyesight, ruining magnificent sights such as Kilchurn Castle, ScotlandCredit: Lenstore

Loss of color

When a person with diabetes begins to lose their color vision, it’s usually the blues and yellows.

The loss of color vision can worsen with the severity of other diabetes-related eye conditions, such as diabetic retinopathy.

Color blindness is a condition where patients are unable to see the correct color of their surroundings.

When a person with diabetes begins to lose their color vision, it's usually the blues and yellows.  Brighton Pier has lost its sun

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When a person with diabetes begins to lose their color vision, it’s usually the blues and yellows. Brighton Pier has lost its sunCredit: Lenstore
Vision loss can be devastating for people with diabetes

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Vision loss can be devastating for people with diabetesCredit: Lenstore

Loss of vision

Although diabetes does not cause blindness, it increases the risk of developing serious eye problems such as diabetic retinopathy.

Over time, these conditions can lead to permanent loss of vision if left untreated.

If your blood sugar is managed, you can slow down and reduce the severity of its impact on your vision.

Eye doctor reveals simple test to find out if you need glasses – so you lose your sight

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2022 NFL Draft: Evaluators expect at least three QBs to go to first round despite lack of consensus https://web-xpress.com/2022-nfl-draft-evaluators-expect-at-least-three-qbs-to-go-to-first-round-despite-lack-of-consensus/ Sun, 28 Nov 2021 13:09:38 +0000 https://web-xpress.com/2022-nfl-draft-evaluators-expect-at-least-three-qbs-to-go-to-first-round-despite-lack-of-consensus/ While the 2022 quarterback’s draft class isn’t seen as potentially transcendent like some recent classes, and lacks the hype and fanfare at the end of the college football season, many evaluators have watched them closely. think at least three are likely to be selected. in the first round. There hasn’t been anyone who has put […]]]>

While the 2022 quarterback’s draft class isn’t seen as potentially transcendent like some recent classes, and lacks the hype and fanfare at the end of the college football season, many evaluators have watched them closely. think at least three are likely to be selected. in the first round.

There hasn’t been anyone who has put together an overwhelming cumulative body of work like Trevor Lawrence, the overall top pick a year ago, or who has come out of relative anonymity to have a historic Heisman campaign like Joe Burrow. did so the year before, becoming the overall top pick as well. However, the executives I have spoken to, who have seen these quarterbacks play live and several on more than one occasion, believe that at least five or six will deserve consideration in the first round and that some might go down. find themselves in the top 10, given the degree of need for quarterbacks in the league. And none have the kind of otherworldly athleticism that led Kyler Murray, who was also a first-round pick in the MLB Draft, becoming the first pick the year before.

Kenny Pickett of Pitt, Carson Strong of Nevada and Matt Corral of Ole Miss were considered by many of the reviewers to be the top three, most likely, although the order differs depending on the source. Malik Willis of Liberty and Sam Howell of North Carolina are also generating a lot of excitement in the Scout community, but all come with inherent risks. The Boy Scouts don’t defend any of them like they did for Burrow and Lawrence, for example, but several are expected to end up as quality starting quarterbacks in the NFL.

“I think you’ll see three or four end up in the first round,” said an NFL executive who spent much of the fall scouting quarterbacks. “It’s a good class. There isn’t one guy that everyone wants, but I like the band overall.”

One reviewer said he would likely remove the Pickett tops from the group, pointing out that his height (6-3 ½) was the determining factor. Pickett’s decision making, precision and leadership were all qualities that professional recruiters appreciate. “He has a good arm,” said a scout. “It’s not as strong as the kid from Nevada, but it’s strong enough.”

Strong, in the eyes of several reviewers, would be the most wanted of the bunch if it weren’t for medical reasons. He has had several knee surgeries and the medics on a team would need to be very comfortable with him for a club to carry him as high as his sheer potential could warrant. (He missed his entire last season of high school.)

“If he has a good Senior Bowl and the medicals are clean enough, then he will be The Guy,” as one reviewer put it. “He’s a professional passer.”

Corral, at 6 feet and just over 200 pounds, will raise some concerns about durability. Plus, playing in what is primarily a one-read offense portends a learning curve to the next level. “He’s very comfortable and relaxed playing this position,” said one scout. “He can play with his feet and has a great football IQ. But at this height can he hold up?”

Howell entered the season with arguably the highest expectations of anyone in the squad, but didn’t have the season some expected. “Is he going to be able to fit in the pocket and have the vision to pass under pressure?” said an executive. “This is my biggest question with him.”

Willis has had issues with some of his decision making, which could end up withholding his project stock. “He’s the best athlete in the class,” said the executive, “and he’s got all the intangibles you want. But he’s still really a work in progress and interceptions are a concern.”

Some evaluators believe Desmond Ridder, in leading Cincinnati to a historic season, will also be in that mix and be among the top quarterback picks in this draft, with first-round consideration not out of the question. “The kid is special enough to run outside the numbers and he can throw the ball deep,” said a scout. “I have some issues with its accuracy, but it’s an interesting prospect.”


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Parkinson’s disease: signs include dry eye, double vision, and eyelid apraxia https://web-xpress.com/parkinsons-disease-signs-include-dry-eye-double-vision-and-eyelid-apraxia/ Wed, 24 Nov 2021 11:38:48 +0000 https://web-xpress.com/parkinsons-disease-signs-include-dry-eye-double-vision-and-eyelid-apraxia/ About one in 500 people are thought to be affected by Parkinson’s disease, according to the NHS. People with the disease can experience a range of different symptoms. Although there is currently no cure for Parkinson’s disease, early diagnosis is important so that patients can receive the correct treatment and advice regarding care. Parkinson’s UK […]]]>

About one in 500 people are thought to be affected by Parkinson’s disease, according to the NHS. People with the disease can experience a range of different symptoms. Although there is currently no cure for Parkinson’s disease, early diagnosis is important so that patients can receive the correct treatment and advice regarding care.

Parkinson’s UK claims that people with Parkinson’s disease “often have problems with their eyes and their sight as a result”.

Some people may have eyelid apraxia, which occurs when the muscles that open the eyelids have trouble opening. This can often happen during speaking.

The association says, “Sometimes the eyelids can close completely and prevent you from seeing properly. In mild cases of eyelid apraxia, simply rubbing the eyelids can help.

These include difficulty moving the eyes, which may be more noticeable when looking at fast-moving objects, and blurred vision which can be caused by difficulty moving the eyes.

READ MORE: B12 deficiency: the sign around the eyes that can warn that the levels are low

Other people have double vision, which is when you see two images of the same object at the same time.

People with Parkinson’s disease may blink less often than others, which can make your eyes dry or sore.

The charity says, “You might find it difficult to see in low light levels. You may also be unable to clearly distinguish the shape of things, such as a light-colored object on a light background. It can also affect your ability to read the fine print.

Some people with Parkinson’s disease find it difficult to tell the difference between certain colors, and you may find it difficult to judge the space around you.

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Others will have problems with glasses, explains the association. Indeed, some people with Parkinson’s disease find that their posture becomes hunched, “which causes problems if they wear glasses.”

There are several other symptoms and signs to look out for, and the NHS says there are three main symptoms of the disease.

These are involuntary shaking of parts of the body, slow movements and stiff, inflexible muscles.

“See a general practitioner if you are concerned about showing symptoms of Parkinson’s disease. They will ask you questions about the problems you are having and may refer you to a specialist for further testing, ”the site adds.

Most people with Parkinson’s disease start to develop symptoms when they are over 50, and there are several symptoms and signs to look out for.

Although there is currently no cure, there are many different therapies and factors that can help manage the condition, depending on the health care organization.

The Mayo Clinic says, “Because the cause of Parkinson’s disease is unknown, the proven ways to prevent the disease also remain a mystery.

“Some research has shown that regular aerobic exercise may reduce the risk of Parkinson’s disease.”

For example, getting 2.5 hours of exercise per week may slow the progression of your symptoms, according to Parkinson’s UK.

Exercise can help you manage physical symptoms and other symptoms like sleep problems, fatigue, mood and mental health, according to the association.

The Parkinson’s Foundation says, “There are many drugs available to treat the symptoms of Parkinson’s disease, although none yet reverse the effects of the disease.

“It’s common for people with PD to take a variety of these drugs – all at different doses and at different times of the day – to manage symptoms,” he adds.


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NFL insider notes: Eagles on run that could lead them to the playoffs, Browns, Bills in trouble https://web-xpress.com/nfl-insider-notes-eagles-on-run-that-could-lead-them-to-the-playoffs-browns-bills-in-trouble/ Mon, 22 Nov 2021 13:20:00 +0000 https://web-xpress.com/nfl-insider-notes-eagles-on-run-that-could-lead-them-to-the-playoffs-browns-bills-in-trouble/ Fly eagles fly! Fly eagles fly! Okay, it’s more: Run Eagles Run! Course Eagles Course! But it does not matter. Let’s not let semantics get in the way of a football streak that alters the narrative of the team playing in Philadelphia. Because the Eagles are playing some of the most interesting football in the […]]]>

Fly eagles fly! Fly eagles fly!

Okay, it’s more: Run Eagles Run! Course Eagles Course!

But it does not matter. Let’s not let semantics get in the way of a football streak that alters the narrative of the team playing in Philadelphia. Because the Eagles are playing some of the most interesting football in the NFC right now – they’re off the mat and they’ve crept in screaming distance of the playoff pursuit. Just weeks after so many seemed ready to kick rookie head coach Nick Sirianni out of town, with near-rookie QB Jalen Hurts with him (he’s only started a calendar year), the Eagles are approaching .500 with a slew of division games still to play and a chance to be high on their Week 14 recess.

The Eagles have won three of their last four games, and they’re ranking opponents and racking up points. They have scored 138 points (!) During that time. Yes, it is quite substantial. Even the loss of Jordan Howard to injury didn’t slow them down on Sunday as they passed through the Saints, with Hurts again in the lead. Hurts continues to protect football, make the shots that are there and provide a spark of improvisation in the hard-to-defend running game. They ran 242 yards on a tough New Orleans defense – making it pretty clear that their intention wouldn’t involve a lot of downward intention.

Everyone knew they were running; nobody could do much about it. This is how you accumulate 37 minutes of possession time.

The Eagles entered that game with a record 761 rushing yards in the NFL since Week 7 – already 136 yards more than anyone in that span – and then widened that lead on Sunday. Miles Sanders is back in great shape. Defense is improving. And things could fall into place for Philly to kick off a bit… maybe even the one that will get them playing meaningful games in January. Because, yeah, 5-6 isn’t great, but 9-8 and maybe 8-9 gets you in the game, and the Eagles are 4-3 in the conference, including wins over. head to head against potential wild card teams like New Orleans and Carolina. Food for thought.

They play for the Giants and Jets – imperfect teams themselves – for the next two weeks before their leave; it basically comes down to bus rides to the New Jersey Turnpike. After the week off, they play three of the last four games at home, with the only game on the road (Washington) also being essentially a bus trip. So, for all intents and purposes, their real journey is already behind them before Thanksgiving.

The Eagles have WFT and the Giants at home and in Week 18 they will face a Cowboys team that will most likely be locked in a playoff spot and eager to rest everyone ahead of the playoffs (or maybe that the first seed is already locked). Either way, keep an eye out for the Eagles. I like where they go.

Browns need a quick fix

Anyone else remember when the word was that Odell Beckham Jr. was holding back the Browns offense? Yeah, how ridiculous does that look now?

Cleveland has been reduced to a fairly predictable attacking outfit at this point, as their 13-10 home Lions survival highlighted. Baker Mayfield’s limits are further exposed as he plays despite injuries, and the loss of right tackle Jack Conklin appears to be a real problem. There isn’t much this attack can count on right now apart from Nick Chubb, wide injuries made their problems worse, and they’re really lucky the Lions were playing with Tim Boyle in QB during of his NFL debut because they probably lost to someone else.

And there is nothing exciting about this defense either. For the second week in a row, he was cut to the ground. The Lions picked up where the Patriots left off – D’Andre Swift left and Cleveland suddenly gave up 352 rushing yards in just two weeks. They aren’t built to play from behind right now, they don’t do a lot of quick hitting and they’ll face Baltimore twice over the next three weeks, with a bye in between.

They have a lot to deal with and little time with a busy schedule looming. The Browns are 3-3 in their last six games and have been limited to 17 points or less in five of them, and 10 or less in two of them. The Browns won 41 points against the Bengals three weeks ago, but produced a total of 61 points in their other five most recent games.

Bill breach has lost its mojo

The Bills offensive line looks week’s worst, mistakes and turnovers keep piling up and at this point I’m not sure you can even expect Buffalo’s offense to ever look like the level at which it’s been running for most of 2020. It’s just not there. It’s not here with Stefon Diggs like it was a year ago. It’s not here with Josh Allen either. And as I pointed out a week ago in what turned into a possible resounding victory over the lowly Jets, things are very hit and miss and the pace has been hard to find. Allen has almost pitched as many picks as all of last season (8-10) already, his completion percentage and TD percentage have dropped significantly, and his QB rating is 10 points lower than a year ago. year. And take a look at the upcoming Bills schedule. This is not a joke.

Yeah, it’s really time to worry if Trevor Lawrence is in good hands with Urban Meyer. There were plenty of reasons to give the property a break over this hire – some of them unprecedented – but most of all the terrible decisions and the lack of judgment and embarrassment it caused. To himself and to the franchise, perhaps worst of all is what’s going on with the development of the overall first choice.

You can check out my Sunday morning report for more details, but in the end, Lawrence has been wild again this week. He’s a 9-for-22 combined for 99 yards in the first half of the last two games. The Jags have a total of seven first tries in these halves. Luckily they handed out Gardner Minshew or maybe he’s playing there! Seriously, things got a little better during the garbage time – as they tend to do, ask Blake Bortles – but it’s not going in a positive direction.

More notes on week 11

  • And the Lions? AFC North seems to bring out the best in them. It took a staggering game penalty delay and the longest field goal in NFL history for the Ravens to beat them, the Lions tied the Steelers last week (and frankly should have won that game too. ), then they almost beat the Browns on Sunday. Yes, the Bengals destroyed them, but it was a great performance for a 0-9-1 team against what some thought was the best division in football.
  • Is Jonathan Taylor making his way into the MVP conversation? May be. May be. But I had a feeling the Colts would fight their way to a win on Sunday and as long as Carson Wentz avoids the kind of silly forced mistakes that tend to happen, they look like a playoff team to me.
  • I have to give Steve Spagnuolo major props for knocking down the Chiefs’ defense. They’re releasing Chris Jones again and this unit has come a long way in the past six weeks.
  • There has been a lot of talk around the NFL that losing Derrick Henry will catch up with the Titans soon enough, and their magic carpet ride will run into trouble. Just surprised it was against Houston, in a relative landslide, on a day the Texans are averaging 3.1 yards per game. It’s hard to do, even when the QB is throwing four picks. Also at the height of the AFC course, where no one keeps this potential seed for very long without reopening the race right away.
  • It was a borderline crime for Wink Martindale to call for a total blitz, sending eight out of fourth and 11 in the final minutes to milk a two-point lead, but all credit to the Ravens for continuing to breathe the wit and determination under duress. Earning another comeback victory – and this time with replacement QB Tyler Huntley in his first NFL start, on the road no less – is no joke, and they continue to overcome injuries and adversity at image of head coach John Harbaugh. They’re not lacking in guts, that’s for sure.


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Ocugen action: bull against bear https://web-xpress.com/ocugen-action-bull-against-bear/ Sat, 20 Nov 2021 11:40:00 +0000 https://web-xpress.com/ocugen-action-bull-against-bear/ When it comes to disputed stocks, Ocugen (NASDAQ: OCGN) is probably one of the market leaders. The company is trying to commercialize its coronavirus vaccine candidate and also has long-term growth potential stemming from its developing gene therapy group for eye disorders. It’s easy to see why there is so much interest in its value […]]]>

When it comes to disputed stocks, Ocugen (NASDAQ: OCGN) is probably one of the market leaders. The company is trying to commercialize its coronavirus vaccine candidate and also has long-term growth potential stemming from its developing gene therapy group for eye disorders. It’s easy to see why there is so much interest in its value as an investment.

With a market cap of just $ 1.6 billion, it could have a huge amount of leeway. Let’s take a look at an argument for buying Ocugen shares and an argument against to get a better idea of ​​if it would be a good choice for your portfolio.

Image source: Getty Images.

A better approach to gene therapy

Patrick Bafuma: Ocugen is undervalued and underrated compared to his peers.

Let’s talk about Covaxin first. The nascent biotech COVID-19 vaccine candidate has already been filed for emergency use authorization (EUA) in the United States for patients between the ages of two and 18. Not only is this a younger age group than the Modern (NASDAQ: mRNA) and Pfizer (NYSE: PFE) The mRNA vaccines have been authorized, but it is also a totally different form of vaccine.

Covaxin uses an inactivated viral platform – the type we all grew up with that has been used for decades in the pediatric population. Sure, the two mRNA vaccine makers have a head start, but with a market cap of $ 1.7 billion, it won’t take much revenue to impact Ocugen. Despite concerns about decreased effectiveness and increased risk of some types of rare blood clots, even Johnson & johnson‘s (NYSE: JNJ) The single-dose, mRNA-free, adenovirus vaccine generated $ 421 million in the United States in the first nine months of 2021. People who are hesitant about the risks of clotting and the decreased effectiveness of the Johnson & Johnson vaccine, as well as the novelty of mRNA vaccines may be willing to accept the OcuGen vaccine. In addition, being able to be stored for about two years at 2 ° to 8 ° C and three months at room temperature, Covaxin is easier to administer in doctor’s offices.

But at the end of the day, any money for the COVID-19 vaccine is likely a path to fuel its goal of becoming an ocular gene therapy solution. The company believes it can treat multiple types of genetic retinal degeneration with just one drug. In advanced stages of the disease, these rare eye disorders can cause blindness, but Ocugen’s flagship treatment, OCU400, aims to change that. And the one-drug approach to treating multiple rare genetic eye diseases might be a better business plan than competitors chasing them one at a time.

Using the well-researched adenovirus delivery system, early studies in mice suggest that OCU400 may halt disease progression and save vision in both early and late stages of the disease. If – and this is a big if – he can replicate that in human trials, it will be more promising than Nightstar Therapeutics when it was bought by Biogenic for $ 877 million in 2019. In these phase 1/2 trials, Nightstar treatment was not curative, showing only signs of improvement in visual acuity in some patients and possibly slowing progression of disease. Spark Therapeutics, acquired by rock for $ 4.8 billion in 2019 after its treatment for rare eye diseases was approved, tackled rare genetic eye diseases one by one.

Ocugen has a better mousetrap than other ophthalmic gene therapy companies today and costs a fraction of the price. In addition, it has potential income from vaccines close to the EUA to reduce research and development costs.

Vaccine market share is not guaranteed

Alex Carchidi: Ocugen’s coronavirus vaccine could be a winner for shareholders, but it will have to overcome a few key hurdles that I doubt it will.

More importantly, his Covaxin jab is only cleared for development in the United States and Canada. Both of these markets are already teeming with highly effective products from strong competitors such as Pfizer, Moderna and Johnson & Johnson.

And, by the time Covaxin is approved for sale, Ocugen could be in competition with other vaccine laggards like Novavax too much. It might be difficult for Ocugen to sell its product to the US and Canadian governments, which have already had purchase agreements with major manufacturers for over a year.

Of course, this assumes that Ocugen’s jab is approved, which is not guaranteed. Because they are relying on clinical trial data from Bharat Biotech rather than conducting their own efficacy studies in people between the ages of two and 18, US regulators may be inclined to dismiss the petition. Ocugen for an Emergency Use Authorization (EUA) for children. A request for more data wouldn’t mean Ocugen’s jab is doomed, but it would almost certainly be a blow to the stock.

The other problem is that Covaxin is formulated against the original SARS-CoV-2 virus rather than the destructive variant Delta, which probably makes it only 65.2% effective. The same goes for the company’s competitors, but especially for heavyweights like Moderna and Pfizer, variant-specific vaccine candidates have been in the works for some time now.

So, they will likely release anti-variant booster shots while Ocugen will likely market his jab against the original version of the virus, assuming he will have to do a few more clinical trials before getting an EUA from the regulators. This will not be favorable to its sales potential, to say the least.

Aside from those issues that could hamper his jab’s adoption timeline, Ocugen has all of the standard risks, issues, and warnings of every biotech startup. While its ocular gene therapy platform could one day produce some great value programs, as of yet, it has absolutely not been proven to work. The company does not have commercial stage programs that have been developed in-house, which means that investors take a very large part of the risk of potential failures during the clinical development process. It will be years before any of his in-house programs even have a chance to generate income, if they ever do.

This stock is not for everyone

It’s entirely possible that investors will see Ocugen shares soar as a result of its vaccine work, and the company could easily use the proceeds from jab sales to fund the development of its pipeline programs. gene therapy down the line.

Hence, it is a great option for people looking to make a speculative buy. But, in light of the difficulty it will face in gaining market share and its lack of mature pipeline programs, more conservative investors should probably ditch this stock in favor of something less risky.

This article represents the opinion of the author, who may disagree with the “official” recommendation position of a premium Motley Fool consulting service. We are heterogeneous! Challenging an investment thesis – even one of our own – helps us all to think critically about investing and make decisions that help us become smarter, happier, and richer.


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Man with rare disease sees cartoon vision, can’t recognize grandchild https://web-xpress.com/man-with-rare-disease-sees-cartoon-vision-cant-recognize-grandchild/ Thu, 18 Nov 2021 17:26:35 +0000 https://web-xpress.com/man-with-rare-disease-sees-cartoon-vision-cant-recognize-grandchild/ A man with a rare disease that severely affects his vision has opened up about his daily struggle with hallucinations and his inability to recognize faces. Graham Varley suffered several strokes in 2017, leading to massive loss of vision and the development of a condition known as Charles Bonnet syndrome, according to Leeds Live. This […]]]>

A man with a rare disease that severely affects his vision has opened up about his daily struggle with hallucinations and his inability to recognize faces.

Graham Varley suffered several strokes in 2017, leading to massive loss of vision and the development of a condition known as Charles Bonnet syndrome, according to Leeds Live.

This sometimes causes the 56-year-old to see things that are not real, as well as problems with identifying people.

Graham, of Chapel Allerton, said: “What has happened to me is so rare and so strange and it has been really horrible to deal with. I wouldn’t wish it on anyone. But four years later I feel like to have started to live again. ”

A bakery manager at the time, Graham started having a headache one day about four years ago while at work, but continued as usual.

His colleagues noticed that something was wrong – when he collapsed he was immediately taken to hospital.

The blood had been cut from the main artery to his brain, leaving him with hemianopsia on the right side – the loss of half of your visual field.

By Christmas Day in 2017, most of Graham’s sight was gone.

Graham said: “After my shots I not only had to relearn everything like reading and writing, and even learning to dress, but I also lost the majority of my vision – and on Christmas Day. everyday.



Graham suffered several strokes in 2017 that affected his vision.

“The only sight I have left is a little bit to the top right of my eyes – I can’t focus and have no perception of 3D, so everything I can see looks like a cartoon.

“One of the most disturbing things caused by my loss of sight is Charles Bonnet syndrome, which makes me see things that are not there.

“Sometimes it can be things of a different color than they are, like pink grass or a purple tree, but other times it can make me hallucinate which can be quite enough. scary – like a car coming towards me, or quite often, huge cobwebs.

“I also now have something called prosopagnosia, which means I can’t recognize people’s faces. I have a two year old granddaughter and because I never knew what she really looks like, my condition makes her look like me every time I see her.

“My doctor tells me that I still have two blood clots in my brain that are dormant, but they can move and my eyesight is changing all the time because the signals are not going to the right place.

“So some days I look at Griffin, my guide dog, and with the partial vision I have, he looks like a cartoon dog. “

After Graham left the hospital, he spent a year waiting for help and had to rely on family, friends and caregivers.



Graham says the Griffin guide dog helps him see what's real and what isn't.
Graham says the Griffin guide dog helps him see what’s real and what isn’t.

He was essentially assigned to several specialists and was eventually partnered with guide dog Griffin in November 2020.

He has since fallen in love with the black Labrador Griffin, who supports him in his daily life after being affected by Guide Dogs UK.

“Oddly enough, I didn’t like a black Labrador, but when Griffin came on the scene, within 24 hours, I was wowed!” Graham said.

“I’ve had dogs my whole life, but I’ve never trusted one like I do now. We go out every day together – he has opened up my life so much. The farthest I went was all the way to the end of my driveway and back, but now we’re walking three or four miles a day.

“With my Charles Bonnet Syndrome, Griffin helps me know what’s real and what isn’t. If I see something in front of me but Griffin keeps walking, I know it’s a hallucination.

“Yesterday, with Griffin by my side, it was the first time I went to the supermarket alone in four years. A few weeks ago, it was the first time since my stroke that I went to the barbers. I feel like I’ve regained my confidence – I haven’t done anything I’m doing now, without Griffin.

“I even took him to the pub and everyone must know him – he’s going to say hello to everyone and now he’s a local celebrity!”

“I have never trusted anyone like Griffin – he is truly amazing and I am so grateful to the guide dogs and the team for their support.”

Graham lives with his wife Mandy and is also in the care of a caregiver.

He has four children and five grandchildren – he teaches his 12-year-old granddaughter how to cook to follow in his footsteps.

He loves going to the beach with Griffin and hopes to move to the seaside in Filey next year.


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Planners land contracts at Dubai Airshow https://web-xpress.com/planners-land-contracts-at-dubai-airshow/ Tue, 16 Nov 2021 16:59:00 +0000 https://web-xpress.com/planners-land-contracts-at-dubai-airshow/ DUBAI, Nov. 16 (Reuters) – Global aerospace companies have secured provisional or firm orders for more than 400 planes at the Dubai Airshow, building on signs of a recovery from a shattering global pandemic industry profits. After large orders for narrow-body aircraft and a new freighter earlier this week, Airbus (AIR.PA) has reached an interim […]]]>

DUBAI, Nov. 16 (Reuters) – Global aerospace companies have secured provisional or firm orders for more than 400 planes at the Dubai Airshow, building on signs of a recovery from a shattering global pandemic industry profits.

After large orders for narrow-body aircraft and a new freighter earlier this week, Airbus (AIR.PA) has reached an interim agreement for up to 30 A320neo narrow-body aircraft from Kuwaiti company Jazeera Airways, while Boeing ended a recent shortage of orders in India.

Most of the planes ordered were narrow-body models most in demand by low-cost carriers like European Wizz Air (WIZZ.L) and Boeing’s latest customer, Indian startup Akasa.

“I think this is a sign of recovery. The second half of the decade in which most of these planes will be delivered is a very long time away, so it is reasonable to expect that at this point, traffic exceeds pre-COVID levels, ”he added. said independent aviation advisor Bertrand Grabowski.

“It is also reasonable to expect those who emerge from the crisis with lower costs and higher efficiency to win,” he added.

A major question mark hangs over Asia, previously the engine of demand for new airliners, executives said, while some worried about the concentration of orders among a few carriers.

Airlines and suppliers have nonetheless grasped signs of a fragile recovery, using the airshow advertising deadline to try to secure last-minute concessions.

The deal between Airbus and Kuwait Jazeera comes after the president of the airline, Marwan Boodai, told Reuters this month that the low-cost carrier aims to buy up to $ 2 billion in jet planes.

Akasa Air, backed by billionaire Rakesh Jhunjhunwala, has finalized an order for 72 Boeing (BA.N) 737 MAX jets, which will help the US aircraft manufacturer regain lost ground in one of the fastest growing markets in the world. Read more

Boeing is also counting on the order to provide further support for the MAX, which remains anchored in China after a nearly two-year security ban that was lifted in the West late last year.

The deal includes a high-density 200-seat version of the Boeing 737 MAX known as the 8200, making Akasa the layout’s second major customer after Ireland’s Ryanair (RYA.I), which is struggling with a dispute with Boeing on the prices of the new planes.

The 8200’s configuration is suitable for ultra-low-cost carriers focused on reducing costs per seat, although industry sources have said Akasa would also have to fight for competitive airport costs to be successful in the market. choppy air from India.

Nigerian carrier Ibom Air, owned by the Akwa Ibom state government, has confirmed an agreement for 10 Airbus A220s.

RULES AT BORDERS

Widebody demand at the base of major Gulf travel hubs like Dubai and Doha, whose carrier Qatar Airways is missing from this year’s show amid persistent diplomatic injuries in the region following a recent rift between Gulf states, remains low as international travel slowly recovers from pandemic restrictions.

“Once we see the easing of borders, entry requirements and all the other extras with people traveling these days… then you will see the rebound in the countries we are flying to now,” the president said. from the Emirates, Tim Clark.

The Emirates executive urged Boeing to provide firm dates for its delayed 777X, saying the uncertainty of certification has upended the carrier’s growth plans. Boeing did not immediately comment.

Emirates is the largest customer of the previous version of the 777 as well as the Airbus A380 superjumbo, whose production is halted due to weak sales.

Clark, who has been among the A380’s greatest champions, has predicted the double-decker aircraft will prove its mettle when travel recovers from the COVID-19 crisis. Some other industry leaders are seeing a move towards smaller, more flexible jets.

As supply chain issues hit manufacturing around the world, Clark said Airbus was unable to give a date for “even the last” delivery of the A380 that was scheduled for the mid-December.

He also noted that labor shortages were hurting the industry.

An Airbus spokesperson said: “All deliveries are agreed with the customer and it is the customer’s privilege to announce them.”

Reporting by Tim Hepher, Alexander Cornwell, Aditi Shah, Jamie Freed Editing by Keith Weir, Bernadette Baum and Bill Berkrot

Our Standards: Thomson Reuters Trust Principles.


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Opus Genetics announces agreement with Massachusetts Eye https://web-xpress.com/opus-genetics-announces-agreement-with-massachusetts-eye/ Thu, 11 Nov 2021 15:36:27 +0000 https://web-xpress.com/opus-genetics-announces-agreement-with-massachusetts-eye/ RALEIGH, NC, Nov. 11, 2021 (GLOBE NEWSWIRE) – Opus Genetics, a patient-centered gene therapy company that develops treatments for inherited orphan retinal diseases, today announced an agreement to license its third preclinical program to treat mutations in the NMNAT1 gene, which cause a specific form of Leber’s congenital amaurosis (ACL), from the Massachusetts Eye and […]]]>

RALEIGH, NC, Nov. 11, 2021 (GLOBE NEWSWIRE) – Opus Genetics, a patient-centered gene therapy company that develops treatments for inherited orphan retinal diseases, today announced an agreement to license its third preclinical program to treat mutations in the NMNAT1 gene, which cause a specific form of Leber’s congenital amaurosis (ACL), from the Massachusetts Eye and Ear, the main teaching hospital of Harvard Ophthalmology.

The new program, OPGx-003, is based on the work of Eric Pierce, MD, Ph.D., director of the Ocular Genomics Institute and William F. Chatlos professor of ophthalmology at the Massachusetts Eye and Ear and the Harvard Medical School, and co-founder of Opus. OPGx-003 is a gene augmentation therapy designed to arrest functional deterioration in pediatric patients with degenerative retinal disease caused by mutations in the nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) gene. Recent preclinical data have demonstrated the potential of this gene augmentation approach to achieve stable rescue of retinal structure and function. Opus plans to file an IND for OPGx-003 in the first half of 2023.

“We are delighted to collaborate with Dr. Pierce, who will bring his expertise in retinal gene therapy to the search for a novel treatment for retinal degeneration associated with NMNAT1,” said Ash Jayagopal, Ph.D., Scientific Director of NMNAT1 Opus Genetics. “The addition of OPGx-003 to the Opus pipeline further underscores our commitment to bringing together the resources and expertise necessary to take promising science from the laboratory to the clinic and ultimately to the patients who need it, and strengthens the importance of our innovative patient-centric model. . “

“I saw with my own eyes the need for new treatments for rare inherited retinal diseases,” said Dr. Pierce. “As someone who has dedicated my life to researching this space, I firmly believe that Opus is an ideal company to advance this work and make a difference for patients in need.”

Opus’ main program, OPGx-001, is designed to process mutations in the LCA5 gene, which encodes the lebercilin protein. The company’s second program, OPGx-002, will focus on restoring protein expression and stopping functional deterioration in patients with retinal dystrophy caused by mutations in the retinal dehydrogenase (RDH12) gene. (LCA13).

About Opus Genetics
Opus Genetics is a revolutionary gene therapy company for inherited retinal diseases with a unique model and purpose. Backed by the venture capital arm of the Foundation Fighting Blindness, the RD Fund, Opus combines unparalleled insight and commitment to the needs of patients with wholly owned programs in many orphan retinal diseases. Its portfolio of AAV-based gene therapy tackles some of the most neglected forms of inherited blindness while creating a new scale and efficiency of orphan manufacturing. Based in Raleigh, North Carolina, the company leverages the insights of top scientists and the expertise of pioneering ocular gene therapy to seamlessly drive transformative treatments for patients. For more information, visit www.opusgenetics.com.

Disclosures
Dr Pierce owns shares and is a consultant for Opus Genetics.

Media contact:
Heather anderson
919-827-5539
handerson@6degreespr.com


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Optometry residency | VA Spokane Healthcare https://web-xpress.com/optometry-residency-va-spokane-healthcare/ Tue, 09 Nov 2021 20:43:57 +0000 https://web-xpress.com/optometry-residency-va-spokane-healthcare/ Mission of the residency program The fundamental mission of this training program is to provide qualified postgraduate practitioners with a structured educational experience that will broaden their development into outstanding optometric clinicians in the areas of primary care, geriatrics, eye disease, specialized contact lenses and co-management. surgical. . Upon completion of the residency, the clinician […]]]>

Mission of the residency program

The fundamental mission of this training program is to provide qualified postgraduate practitioners with a structured educational experience that will broaden their development into outstanding optometric clinicians in the areas of primary care, geriatrics, eye disease, specialized contact lenses and co-management. surgical. . Upon completion of the residency, the clinician will emerge with enhanced clinical skills, knowledge and experience that will elevate them beyond entry-level practice, making residents suitable candidates for optometric positions in the field. co-management, multidisciplinary settings and / or graduate studies. optometry training.

Patient care experience

This program offers a diverse patient care experience.

Residents see 13 to 15 patients per day at the VA Eye Clinic. Here, residents receive training in primary eye care, part of an interdisciplinary team working to provide comprehensive, high-quality health care to the veteran. With a predominantly geriatric patient population, eye disease management is an important part of the training experience. Residents provide direct patient care at the eye clinic, under the supervision of attending physicians.

Schedule of the program

Starting July 1 and ending June 30 of the following year.

Specific advantages of a VA optometry residency:

  • An exceptional 12-month clinical patient care experience (July 1 to June 30) serving a stimulating and rewarding veteran population.
  • A stimulating interdisciplinary environment where the resident learns to coordinate quality primary optometric eye care services with other healthcare providers to maximize patient care outcomes and learning experiences.
  • Research and academic opportunities supervised by experienced clinicians who are among the most published optometrists in the world.
  • Possibility of focusing either on primary eye care or on combined primary eye care / rehabilitation for low vision.
  • Vacations, holidays and sick leave with authorized absence for approved continuing education.
  • Competitive annual salary.
  • Health and life insurance plans available.

Eligibility criteria

Applicants must be U.S. citizens, have passed the National Board of Optometric Examiners (NBEO) Part I, II, TMOD, and III exams, and have received a Doctorate of Optometry from an accredited school or college of optometry. by ACOE before July 1. of the year of residence. Before the completion of the residency, the applicant is required to obtain a state permit.

Schedule of the program

Starting July 1 and ending June 30 of the following year.

Specific advantages of a VA optometry residency:

  • An exceptional 12-month clinical patient care experience (July 1 to June 30) serving a stimulating and rewarding veteran population.
  • A stimulating interdisciplinary environment where the resident learns to coordinate quality primary optometric eye care services with other healthcare providers to maximize patient care outcomes and learning experiences.
  • Research and academic opportunities supervised by experienced clinicians who are among the most published optometrists in the world.
  • Possibility of focusing either on primary eye care or on combined primary eye care / rehabilitation for low vision.
  • Vacations, holidays and sick leave with authorized absence for approved continuing education.
  • Competitive annual salary.
  • Health and life insurance plans available.

Eligibility criteria

Applicants must be U.S. citizens, have passed the National Board of Optometric Examiners (NBEO) Part I, II, TMOD, and III exams, and have received a Doctorate of Optometry from an accredited school or college of optometry. by ACOE before July 1. of the year of residence. Before the completion of the residency, the applicant is required to obtain a state permit.

Applications

All requests are processed through the Optometric Residence Matching Service (ORMS). Applicants will also need to send the following documents directly to the Residency Program Director at Mann-Grandstaff VAMC.

  • Curriculum vitae
  • Optometric training transcripts
  • Letter of Intent: a brief statement detailing your desire to complete this residency
  • Two (2) letters of recommendation

Site visits and personal interviews can be scheduled by contacting the residency program director.


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The most common problem of bruising under the eyes of the eye circumference https://web-xpress.com/the-most-common-problem-of-bruising-under-the-eyes-of-the-eye-circumference/ Mon, 08 Nov 2021 01:30:40 +0000 https://web-xpress.com/the-most-common-problem-of-bruising-under-the-eyes-of-the-eye-circumference/ The most common problem of bruising under the eyes of the eye circumference The eyes are one of the most striking areas of the face. Eye problems, which arise for different reasons regardless of male or female, annoy people and affect their self-confidence. Specialist in ophthalmology Op. Dr Hakan Yüzer gave important information about dark […]]]>
The most common problem of bruising under the eyes of the eye circumference

The eyes are one of the most striking areas of the face. Eye problems, which arise for different reasons regardless of male or female, annoy people and affect their self-confidence. Specialist in ophthalmology Op. Dr Hakan Yüzer gave important information about dark circles under the eyes. What’s under the bruise? What is the cause of dark circles under the eyes? How does the bruise under the eyes affect the person? How do you treat bruises under the eyes?

What are dark circles under the eyes?

“Dark circles under the eyes” is actually used as a common name for various images around the eyes. It is mainly the light brown to black appearance around the eyes, darker than the normal color of the skin of the cheeks. We call this “pigmentation around the eyes”. Apart from this, there is also a different group characterized by the appearance of veins under the skin, which are red to purple in color.

What is the cause of dark circles under the eyes?

In fact, genetic factors are in the first place. Any situation in which the body’s blood circulation is impaired and the lymphatic system, from which toxins are eliminated, does not function well, causes color changes around the eyes. Even in the initial period of deterioration of these systems, it can manifest as a bruise around the eyes. Smoking, stress, magnetism, heavy metals, insomnia, ultraviolet rays, alcohol, nutritional problems are the cause of the bruises around the eyes.

What is the effect of dark circles under the eyes on the person?

The person looks tired, does not feel good in social life, and tries to cover this problem with various concealers.

How to treat dark circles under the eyes?

Treatment for bruises under the eyes varies individually depending on the reason. After evaluating the causal factors and taking the necessary steps, regularizing the mineral and vitamin balance in the body, and working on anemia and other diseases, which we call anemia, treatment methods such as mesotherapy around the eyes, laser, plasma energy, light fillings under the eyes, ozone and acupuncture one by one or we apply them in combination.

So what are the differences between mesotherapy under the eyes and light filling under the eyes?

Mesotherapy under the eyes is a complex product that contains hyaluronic acid, pigment lightening agents, blood flow regulators, antioxidants, vitamins, minerals, amino acids. Individual, there are differences in their content. This is done in sessions. Between sessions are 7 to 15 days and 4 to 6 sessions are done as needed. It has a therapeutic function around the eyes. Even after the procedure, recovery continues. It can be renewed in the following years. The light filling under the eyes is made of hyaluronic acid bonded by cruciate ligaments, and the eye fountain grooves formed by the reduction of bone structure, muscle structure and fat layer with aging are applied to the edges of the bags under the eyes and the tired expression and the sagging eye area is eliminated. It should be repeated every 9 to 12 months.

To whom can a light filling or mesotherapy be applied?

These procedures are not applied in pregnant women, active infections, psychiatric illnesses and patients with severe illness.

After these applications, how should eye care be at home for a healthy look?

I recommend high-quality sleep habits, not staying on screen for a long time, drinking plenty of water, as well as masks made from natural cosmetics and organic products around the eyes for a healthy eye area.


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